- Application deadline
- Not stated: check the official notice
- Stipend / salary
- As per norms
- Qualifications mentioned
- Master's (MSc/MTech/MPharm), Bachelor's (BSc/BTech/BPharm)
- Posted
- 9 Jun 2026 · Government
About this position
Advertisement No: : NIBMG/ ACAD/PROJECT RECT./2026-27/077 Date:09-06-2026 Position available: Online Interview Project Title: Translational Decoding of TCR-Neoantigen Dynamics in Oral Precancerous Lesions Progression towards Frank Cancer: Integrating Spatial Sequencing and AI for Early Prediction Biomarker Development. Oral Squamous Cell Carcinoma (OSCC) remains one of the leading causes of cancer-related mortality in India, largely driven by late-stage diagnosis and high recurrence rates. While oral precancerous lesions, such as Leukoplakia, are frequently identified during routine screenings, the lack of definitive molecular biomarkers makes it nearly impossible to predict which lesions will undergo malignant transformation. This project aims to bridge that gap by shifting the focus toward early intervention and immunogenomic risk stratification. The project involves - (i) combining high-throughput TCR sequencing with existing somatic mutation, gene expression, and methylation data from oral cancer patients. (ii) utilizing cutting- edge spatial technologies to understand the regulatory roles and architectural nuances of the immune milieu in independent patient cohorts. (III) developing a predictive AI/ML algorithm that integrates immunogenomic features for early disease progression risk assessment. We are looking for motivated researchers to join us in reconstructing the oral cancer progression model.