- Application deadline
- Not stated: check the official notice
- Stipend / salary
- ₹30,000
- Qualifications mentioned
- Master's (MSc/MTech/MPharm), Bachelor's (BSc/BTech/BPharm), MBBS/MD/BDS/MVSc, NET/GATE qualified
- Posted
- 15 Jun 2026 · Government
About this position
_______________________________________________________________________________________________________ Advertisement No.: NIBMG/ ACAD/PROJECT RECT./2026-27/084 Date: 15 - 06 -2026 Position available BRIC-National Institute of Biomedical Genomics (NIBMG) Kalyani is an Institute of Government of India, Ministry of Science & Technology, Department of Biotechnology. The Institute has created the necessary physical infrastructure and critical platform technologies to support research, translation and training in biomedical genomics. Applications are invited for the position of Project Linked Person (Project Associate-I, PA-I) for extramural project to be executed by the BRIC-National institute of Biomedical Genomics, Kalyani. Selected applicants will be appointed initially for one year. The tenure of appointment may be extended depending on performance and availability of funds. Project Name: Investigating the role of Arid1a in chromatin organization: Potential translation to cancer therapy Principal Investigator’s name: Dr. Sriram Sridharan Research Description: Genome instability is a “enabling hallmark of cancer” which can drive activation of the other hallmarks of cancer. Cellular maintenance includes a plethora of endogenous processes including DNA replication, transcription and chromatin organization. Several endogenous and exogenous disruptions frequently interfere with these cellular maintenance processes which need to be counteracted effectively to maintain the integrity of the genome. For this, mammalian systems have developed multiple pathways to counteract replication stress and DNA damage collectively known as the DNA damage response (DDR) pathways. However, the same pathways that normal cells utilize to maintain genome integrity in the face of these damages are also available to cancer cells to help overcome and survive elevated levels of DNA damage, replication stress and therapeutic intervention. Thus, understanding the genomic contexts that induce DNA damage and mechanisms utilized by cells to overcome this stress is very important in understanding cancer aetiology and designing effective therapeutic regimen. SWI/SNF chromatin remodelling factors are a family of ATP-dependent chromatin remodelling complexes that are critical for nucleosomal rearrangements thus allowing for regulation of gene expression. Arid1a is a subunit of this family of proteins, has been shown to have critical roles in regulation of DNA Damage Response (DDR), DNA replication and chromatin organization though complete characterization of these roles needs to be investigated in detail. It has important tumour-suppressor functions and found to be highly mutated across a spectrum of cancers. Loss of function mutations in Arid1a makes it challenging to treat these cancers leading to poor disease prognosis in patients. Studies proposed here focus on the interplay between chromatin organization, DNA damage and genome stability. More specifically, we aim to uncover the role of Arid1a in regulating higher-order genome organization. The overarching goal of this project is